Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses
نویسندگان
چکیده
منابع مشابه
Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses
Drugs and drug combinations have complex biological effects on cells and organisms. Little is known about how drugs affect protein dynamics that determine these effects. Here, we use a dynamic proteomics approach to accurately follow 15 protein levels in human cells in response to 13 different drugs. We find that protein dynamics in response to combinations of drugs are described accurately by ...
متن کاملDrug interactions and lethal drug combinations.
Although the development of drugs of greater potency and efficacy confers on the physician increasing power to treat serious diseases, it also increases the number and seriousness of potential adverse effects and drug interactions which can occur. Most hospital patients receive more than one drug at a time, the average number often being greater than five (Smith, Seidl, and Cluff, 1966). The in...
متن کاملIndividual precipitating factors of Drug Temptation in Addict Women in Tehran: A Grounded Theory Study
Objective: Temptation is the most important factor associated with drugs use relapse. Mostly, women experience more temptation than men and they are more tempted during treatment than men. The present study aimed to explore the individual precipitating factors of drug temptation in addict women in Tehran. Method: The present research was qualitative method of grounded theory. The study populati...
متن کاملPolypharmacy versus Drug Combinations
Drug combinations have been known to be used either for increasing effcctivity or for decreasing side-efFects. It is only when multiple drugs are prescribed without adequate scientific evidence in their favour then such practices need careful scrutiny. Multiple drug use in psychiatry has recently gained currency and so require thoughtful consideration. The term polypharmacy is generally used to...
متن کاملExpression of Lanosterol 14-Demethylase (ERG11) Gene of Three-Drug Combinations in Candida albicans
Patients with impaired immunity are at particular risk of infections with Candida albicans. Antifungal drugs such as azoles commonly used for candidiasis treatment, but drug resistance is one of the most common problems for public health. The aim of this study was to evaluate the expression of lanosterol 14-demethylase (ERG11) gene for three-drug combinations in C. albicans. Disk diffusion and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.02.011